Company

Technology

Discover scalable, instrument-free single cell sequencing technology from Parse Bioscience

Technology Overview


Resources

Explore our collection of resources to learn more about technology and its applications from leading researchers

Resources Overview

Company

Providing researchers single cell sequencing with unprecedented scale and ease

About Parse

Webinars

Watch webinars on Evercode™ technology and its applications.

Getting Started

The Origins and Fundamentals of Single Cell RNA Sequencing

Single Cell RNA Sequencing (scRNA-seq) is helping researchers uncover new insights in ways not possible with traditional bulk RNA sequencing methods. For researchers interested in learning more or just getting started, we’ve developed a series of three educational webinars focused on demystifying scRNA-seq.

In our first webinar of the series, we explored scRNA-seq’s origins and what research questions it can help you answer.

Colleen Palmateer, PhD
Colleen Palmateer, PhD
Field Application Scientist
Parse Biosciences
Watch recorded webinar
Brain

Spatial Heterogeneity of Transcriptomic Variability in Glioblastoma

In this webinar, Federico Gaiti, PhD, from Princess Margaret Cancer Centre, presents information on spatial intra-tumoral heterogeneity of malignant and immune cells in glioblastoma and how the Parse technology is helping Dr. Gaiti’s team advance their work and knowledge in GBM.

Federico Gaiti, PhD
Federico Gaiti, PhD
Assistant Professor
Princess Margaret Cancer Centre
Watch recorded webinar
Bioinformatics Data Analysis

Identifying Distinct Cellular Programs from Single Cell Datasets Using Topyfic

In this webinar, Narges Rezaie, a PhD candidate from the University of California, Irvine, demonstrates how to use topic modeling to identify repeated patterns in single cell data.

Narges Rezaie
Narges Rezaie
PhD Student
UC Irvine
Watch recorded webinar
Crispr

Perturbing and Tracing Tumor Lineages Resistant to NK Cell-Mediated Killing

During the webinar, Dr. Cong and Yuanhao (Jerry) Qu discussed the advancements made possible by CRISPR Detect. They discuss a new single-cell “perturb and trace” system that combines multiplexed Cas12a perturbations with a machine learning-optimized, single-cell evolvable barcoding system.

Le Cong, PhD
Le Cong, PhD
Assistant Professor
Stanford University School of Medicine
Yuanhao (Jerry) Qu
Yuanhao (Jerry) Qu
PhD Student
Stanford University
Anastasia Potts, PhD
Anastasia Potts, PhD
Senior Product Manager
Parse Biosciences
Watch recorded webinar
Alzheimers

Single Cell RNA-seq Sheds Light on the Role of Microglia in Alzheimer’s Disease

In this webinar, Dr. Swarup, demonstrates the protective functions of microglia in reducing CAA, blood-brain barrier dysfunction, and brain calcification. Examination of human AD tissue and iPSC-microglia demonstrates that microglia phagocytose calcium crystals and is impaired by the loss of the AD risk gene, TREM2.

Vivek Swarup, PhD
Vivek Swarup, PhD
Assistant Professor
UC Irvine
Watch recorded webinar
Brain Cancer Tumor

Uncovering Glioblastoma Heterogeneity in Solid Tumor and Tumor-derived in vitro Models

Glioblastoma remains the most common form of brain cancer, exhibiting enormous heterogeneity in the tumor and immune compartments within both the same tumor and between patients. To characterize this heterogeneity within tumor samples and in vitro models, we utilized the Parse Evercode V2 assay to profile whole cells processed from a patient-derived neurosphere line alongside nuclei isolated from a piece of flash-frozen glioblastoma tissue.

This session is part of Parse Biosciences’ 2023 Brain Awareness Month.

Zac Moore, PhD
Zac Moore, PhD
Research Officer
WEHI (Walter and Eliza Hall Institute)
Watch recorded webinar
Covid

Using Single Cell Sequencing to Investigate Murine COVID-19 Mortality

With flexible and scalable solutions available, learn why single-cell sequencing studies are no longer out of reach. Watch the webinar recording where our speaker, Dr. Benjamin Ostendorf, Charité-Universitätsmedizin, Berlin, presents the results of his recent single-cell study, published Sep 2022 in the Journal Nature, on the role of APOE in Murine COVID-19 mortality.

Benjamin Ostendorf, PhD
Benjamin Ostendorf, PhD
Group Leader
Charité-Universitätsmedizin, Berlin
Mostafa Elmaghraby, PhD
Mostafa Elmaghraby, PhD
Technical Sales Manager
Parse Biosciences
Samuel Kroll, PhD
Samuel Kroll, PhD
Sr. Sequencing Specialist
Illumina
Watch recorded webinar
Gene Capture Immune Profiling Tcr

Expanding Single Cell Capabilities with Immune Profiling and Targeted Gene Capture

In this webinar, you will learn about Evercode TCR for immune profiling and Gene Capture for even greater scalability. You will also learn more about Parse’s foundational technology platform, which enables single cell RNA sequencing with no microfluidics instrument required.

Anastasia Potts, PhD
Anastasia Potts, PhD
Senior Product Manager
Parse Biosciences
Charlie Roco, PhD
Charlie Roco, PhD
CTO and Cofounder
Parse Biosciences
Watch recorded webinar
Cancer

Using Single Cell RNA Sequencing (scRNA-Seq) to Examine What Makes Cancer Possible

In this webinar, Dr. Katerina Gurova, Roswell Park Cancer Institute, describes how she used scRNA-Seq to examine whether the transition between one epigenetic state into another makes cells vulnerable to oncogene induced transformation.

Katerina Gurova, PhD
Katerina Gurova, PhD
Associate Professor
Roswell Park Comprehensive Cancer Center
Watch recorded webinar
Alzheimers Brain

Single-cell Transcriptomic Landscape in Alzheimer’s Disease

The gene-regulatory landscape of the brain is highly dynamic in health and disease, coordinating a menagerie of biological processes across distinct cell types. Understanding these regulatory programs requires a holistic experimental and analytical approach. Here, we present a single-cell study of 380,000 nuclei in late-stage Alzheimer’s Disease (AD) using parse biosciences whole transcriptome kit, profiling gene expression in thousands of genes and uncovering vast neuronal and glial heterogeneity in late-stage AD.

Vivek Swarup, PhD
Vivek Swarup, PhD
Assistant Professor
UC Irvine
Watch recorded webinar
WT Crispr Gene Capture Immune Profiling WT

Scaling Your scRNA-Seq Experiments with Parse Biosciences’ Evercode

The average number of cells profiled in single cell RNA sequencing (scRNA-Seq) experiments has doubled each year since 2015. Yet traditional scRNA-Seq technologies have not scaled well nor do they provide straightforward implementation. Join us for a webinar with Parse Biosciences CTO, Charlie Roco. In it, he describes how straightforward it is to get started and scale with Parse’s combinatorial barcoding technology, Evercode.

Charlie Roco, PhD
Charlie Roco, PhD
CTO and Cofounder
Parse Biosciences
Watch recorded webinar
Crispr

Perturbing and Tracing Tumor Lineages Resistant to NK Cell-Mediated Killing

During the webinar, Dr. Cong and Yuanhao (Jerry) Qu discussed the advancements made possible by CRISPR Detect. They discuss a new single-cell “perturb and trace” system that combines multiplexed Cas12a perturbations with a machine learning-optimized, single-cell evolvable barcoding system.

Le Cong, PhD
Le Cong, PhD
Assistant Professor
Stanford University School of Medicine
Yuanhao (Jerry) Qu
Yuanhao (Jerry) Qu
PhD Student
Stanford University
Anastasia Potts, PhD
Anastasia Potts, PhD
Senior Product Manager
Parse Biosciences
Watch recorded webinar
WT

Sox9 links biliary maturation to branching morphogenesis

Type 2 diabetes (T2D) is a known risk factor for cerebrovascular diseases including Alzheimer’s disease (AD), and vascular dementia (VaD). Yet, our understanding of the mechanisms whereby T2D contributes to neurodegeneration and VaD remains poorly defined. In this study, we utilized the db/db murine model of T2D and single nuclei RNA sequencing to determine the effect of T2D on endothelial cell-specific transcriptomic changes in the hippocampus, an important brain memory center.

Hannah Hrncir
Hannah Hrncir
PhD Candidate
Emory University
Watch recorded webinar
WT

snRNAseq reveals hippocampal endothelial dysfunction and impaired permeability in diabetic mice

Type 2 diabetes (T2D) is a known risk factor for cerebrovascular diseases including Alzheimer’s disease (AD), and vascular dementia (VaD). Yet, our understanding of the mechanisms whereby T2D contributes to neurodegeneration and VaD remains poorly defined. In this present work, we utilized the db/db murine model of T2D and single nuclei RNA sequencing to determine the effect of T2D on endothelial cell-specific transcriptomic changes in the hippocampus, an important brain memory center.

Saivageethi Nuthikattu
Saivageethi Nuthikattu
Assistant Project Scientist
UC Davis
Watch recorded webinar
Bioinformatics Data Analysis Getting Started

Getting Started with scRNA-seq: Sequencing and Data Analysis

Single Cell RNA Sequencing (scRNA-seq) is helping researchers uncover new insights in ways not possible with traditional bulk RNA sequencing methods. For researchers interested in learning more or just getting started, we’ve developed a series of three educational webinars focused on demystifying scRNA-seq.

In our third and final webinar in the series, we described unique considerations for sequencing and data analysis when doing scRNA-seq experiments.

Brian Davis
Brian Davis
Field Application Scientist
Parse Biosciences
Watch recorded webinar
Experimental Design Getting Started Sample Prep

Single Cell RNA Sequencing Experimental Design and Sample Preparation

Single Cell RNA Sequencing (scRNA-seq) is helping researchers uncover new insights in ways not possible with traditional bulk RNA sequencing methods. For researchers interested in learning more or just getting started, we’ve developed a series of three educational webinars focused on demystifying scRNA-seq.

In our second webinar of the series, we described unique considerations for experimental design and sample preparation when doing scRNA-seq projects.

Andria Doty, PhD
Andria Doty, PhD
Senior Field Application Scientist
Parse Biosciences
Watch recorded webinar
Getting Started

The Origins and Fundamentals of Single Cell RNA Sequencing

Single Cell RNA Sequencing (scRNA-seq) is helping researchers uncover new insights in ways not possible with traditional bulk RNA sequencing methods. For researchers interested in learning more or just getting started, we’ve developed a series of three educational webinars focused on demystifying scRNA-seq.

In our first webinar of the series, we explored scRNA-seq’s origins and what research questions it can help you answer.

Colleen Palmateer, PhD
Colleen Palmateer, PhD
Field Application Scientist
Parse Biosciences
Watch recorded webinar

Mapping Interactomes: Precision Health through AI, Single-Cell, and Spatial Biology

What You Will Learn:

  • From FASTQ to Publication-Ready Figures: Learn how you can progress from raw data to insightful, publication-ready figures with just a few clicks with Trailmaker.
  • Cutting-Edge Research: Get insights into the groundbreaking work being conducted by Kevin Matthew Byrd and his team.
Kevin Matthew Byrd, DDS, PhD
Kevin Matthew Byrd, DDS, PhD
Assistant Professor
University of North Carolina at Chapel Hill
Vicky Morrison, PhD
Vicky Morrison, PhD
Senior Product Manager, Software
Parse Biosciences
Register for upcoming webinar
WT Mouse Brain

Distressed: Identifying the mechanisms behind stress induced fear and anxiety

In this webinar, Ethan Goodman explains how single-cell sequencing was used to identify the key cells and critical signaling pathways in the brain responsible for a heightened fear response due to social stress in mice, providing insights into the molecular mechanisms underlying stress-related behavioral changes.

Ethan J. Goodman
Ethan J. Goodman
PhD Student
Ohio State University
Register for upcoming webinar
BCR TCR

Single Cell Immune Profiling at Unprecedented Scale

Join us for an informative webinar in which we overview our new single cell BCR and TCR profiling products which enable immune profiling at unprecedented scale. We are also excited to showcase the work of the Reticker-Flynn Lab at Stanford and how they are using single cell immune profiling to understand the process by which tumors evade the immune system and metastasize to invade the body.

Nathan Reticker-Flynn, PhD
Nathan Reticker-Flynn, PhD
Stanford University
Assistant Professor, PI
Cort Breur
Cort Breur
PhD Student
Stanford University
Charlie Roco, PhD
Charlie Roco, PhD
CTO and Cofounder
Parse Biosciences
Watch recorded webinar
WT Crispr Gene Capture Immune Profiling WT

Scaling Your scRNA-Seq Experiments with Parse Biosciences’ Evercode

The average number of cells profiled in single cell RNA sequencing (scRNA-Seq) experiments has doubled each year since 2015. Yet traditional scRNA-Seq technologies have not scaled well nor do they provide straightforward implementation. Join us for a webinar with Parse Biosciences CTO, Charlie Roco. In it, he describes how straightforward it is to get started and scale with Parse’s combinatorial barcoding technology, Evercode.

Charlie Roco, PhD
Charlie Roco, PhD
CTO and Cofounder
Parse Biosciences
Watch recorded webinar
WT

High Sensitivity Single Cell RNA Sequencing with Evercode Whole Transcriptome v2

Single cell RNA sequencing has become a core tool for researchers to understand biology. As scRNA-seq has become more ubiquitous, many applications demand higher scalability and sensitivity. To meet this need, we developed the Evercode Whole Transcriptome v2 solution, a combinatorial barcoding workflow for scRNA-seq with dramatically improved sensitivity, robustness, and unbiased gene expression.

Charlie Roco, PhD
Charlie Roco, PhD
CTO and Cofounder
Parse Biosciences
Watch recorded webinar