Uncovering Spatial Intra-Tumoral Heterogeneity of Malignant and Immune Cells in Glioblastoma

Glioblastoma (GBM) is a malignant brain tumor known for its aggressiveness, limited treatment options, and poor prognosis. The GBM tumor exhibits extensive heterogeneity and cellular plasticity, making it difficult to effectively target and treat. Our project aims to understand cell states in GBM and their governing factors. By analyzing different tumor regions, we seek to identify regionally enriched malignant and immune cell states, explore the impact of the tumor microenvironment on malignant cells, and investigate intercellular communication networks.

To characterize this heterogeneity within tumor samples, the Parse Evercode WT Mini v2 profiled nuclei processed from 4 tumors collected from 4 patients crossing multiple anatomical regions. These findings shed light on the mechanisms responsible for the diverse phenotypes observed in GBM and aid in the development of novel therapies that target specific cell states.

Sample Table