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Providing researchers single cell sequencing with unprecedented scale and ease

About Parse

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Discover scalable, instrument-free single cell sequencing technology from Parse Bioscience

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Uncovering Spatial Intra-Tumoral Heterogeneity of Malignant and Immune Cells in Glioblastoma


Glioblastoma (GBM) is a malignant brain tumor known for its aggressiveness, limited treatment options, and poor prognosis. The GBM tumor exhibits extensive heterogeneity and cellular plasticity, making it difficult to effectively target and treat. Our project aims to understand cell states in GBM and their governing factors. By analyzing different tumor regions, we seek to identify regionally enriched malignant and immune cell states, explore the impact of the tumor microenvironment on malignant cells, and investigate intercellular communication networks.

To characterize this heterogeneity within tumor samples, the Parse Evercode WT Mini v2 profiled nuclei processed from 4 tumors collected from 4 patients crossing multiple anatomical regions. These findings shed light on the mechanisms responsible for the diverse phenotypes observed in GBM and aid in the development of novel therapies that target specific cell states.

Sample Table

PatientRegionSample NameBatchChemistryCell number from split-pipe
1peri-tumoral6237_2222190_ABatch1v1 kit WT57,460
tumor edge6237_2222190_D
solid core6237_2222190_C
solid core6237_2222190_F
2tumor edge6234_2895153_ABatch2v2 kit WTmini13,838
peri-tumoral6234_2895153_B
tumor edge6234_2895153_E
3tumor edge6240_4964941_B
4peri-tumoral6245_4972288_CBatch3v1 kit WTmini9,591
tumor edge6245_4972288_D
tumor edge6245_4972288_E

"A powerful assay to explore complex tumor microenvironments."

-Federico Gaiti, Assistant Professor, Princess Margaret Cancer Centre

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