Single nuclei transcriptomics reveals altered endothelial cell function, permeability, and behavior in diabetic mice

Diabetes (DM) increases cardiovascular and cerebrovascular disease risk. However, the mechanism of DM-associated microvascular dysfunction and neuroinflammation remains unknown. Here we present a global assessment of endothelial cell-specific gene expression and integrated transcriptomics directly addressing hippocampal endothelium in diabetic mice. We identified for the first-time, differential gene expression with strong signatures of cell signaling, activation of pathways for endothelial dysfunction, and neurodegeneration.

We observed that integrated transcriptomic changes, magnetic resonance imaging, and behavioral alterations all associate with blood brain barrier disruption and correlate with the clinical gene profile of dementia patients, revealing opportunities for treatments with specificity for molecular pathology.

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Publication: Single nuclei transcriptomics in diabetic mice reveals altered brain hippocampal endothelial cell function, permeability, and behavior