Insights from Amygdala Subnuclei in Rhesus Monkeys and Humans

Theories of amygdala function are central to our understanding of psychiatric and neurodevelopmental disorders. However, our limited knowledge of the molecular and cellular composition of the amygdala impedes translational research aimed at developing new treatments and interventions.

Here, we use single-nuclear RNA-sequencing from multiple amygdala subnuclei in both humans and rhesus macaques to bridge the gap between preclinical rodent models and human disorders. Comparing rhesus and human amygdala under different conditions, at single-cell resolution, provides a cell-type atlas for the amygdala and brings us one step closer to understanding amygdala-related disorders.