Our kits take you from single cell or single nuclei suspensions through sequencing straight into biological insights.
Target 100s to 1000s of genes to analyze more samples with less sequencing.
Pair guide RNAs with single cell whole transcriptomes.
Transform single cell sequencing output into understandable results.
Parse Biosciences provides researchers with the ability to perform single cell sequencing with unprecedented scale and ease.
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In this pilot experiment, two sporadic Parkinson’s patient-derived induced pluripotent stem cells (iPSCs) samples and two healthy controls were differentiated into dopaminergic neuronal precursor cells (DA-NPCs).
Each sample was prepared in triplicate, to explore batch effects, robustness, and differential gene expression - for a total of twelve samples. The samples were then fixed with Evercode Cell Fixation v2 and barcoded using the Evercode WT Mini v2 kit.
The results of this work are furthering our efforts to expand the collection and differentiation of additional patient lines. The Early Drug Discovery Unit’s ultimate goal is scaling up this research to identify novel biomarkers and mechanistic targets for new drug development.
The Neuro’s Early Drug Discovery Unit operates under the principles of Open Science. To access our protocols and read about our ongoing research, visit https://www.mcgill.ca/neuro/research/eddu.
Explore Summary Report
Digital Gene Expression (DGE) Matrix (1.2 GB)
All Genes (CSV)
Cell Metadata (CSV)