Our kits take you from single cell or single nuclei suspensions through sequencing straight into biological insights.
Target 100s to 1000s of genes to analyze more samples with less sequencing.
Pair guide RNAs with single cell whole transcriptomes.
Transform single cell sequencing output into understandable results.
Parse Biosciences provides researchers with the ability to perform single cell sequencing with unprecedented scale and ease.
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The genetic absence of microglia in Alzheimer’s disease mice causes a shift from parenchymal amyloid plaques to cerebral amyloid angiopathy, brain calcification, hemorrhages, and premature death (Shabestari et al.). A single injection of adult microglia prevents each of these pathological changes - demonstrating that microglia protect the brain against detrimental Alzheimer’s disease co-pathologies. These results indicate the protective functions of microglia in reducing cerebral amyloid angiopathy (CAA), blood-brain barrier dysfunction, and brain calcification.
Data was generated using the Parse WT kit on nuclei from brain tissue. 8 mice (4 female/4 male) were used in 6 experimental conditions listed below. Many different neuronal, glial, and vascular cell types, including region-specific excitatory neurons, inhibitory neurons, multiple subtypes of astrocytes and oligodendrocytes, and an immune cell population containing signatures of microglia and other immune cells were resolved. Cell types were well mixed across genotype and sex.
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Digital Gene Expression (DGE) Matrix (3.34 GB)
All Genes (CSV)
Cell Metadata (CSV)