ASHG 2023

Parse is excited to attend and exhibit at this year’s American Society of Human Genetics (ASHG) conference. With a mission to democratize single-cell RNA sequencing (scRNA-seq), bringing accessible technology to researchers in the field.

If you would like to learn more about the next evolution of single cell RNA-Seq, our team members will be available to meet with you in person at this year’s ASHG conference. We can’t wait to see you.

Schedule a Meeting


Systematic reconstruction of molecular pathway signatures using massively scalable single cell pooled CRISPR screens

Thursday, November 2 | 12:30-1:30 PM | Room 144A – Lunch will be provided for the first 50 attendees.

Rahul SatijaRahul Satija, PhD
Associate Professor
New York Genome Center

Recent advancements in functional genomics have provided an unprecedented ability to measure diverse molecular modalities across the central dogma. However, the challenge now lies in transitioning from correlative insights to causal understanding. In this session, we describe the potential of genome engineering tools in tandem with single cell RNA-seq readout (i.e. Perturb-seq) to systematically identify the targets of signaling regulators in diverse biological contexts. Specifically, we demonstrate how Perturb-seq is compatible with recent and commercially available advances in combinatorial barcoding (to reduce library preparation costs) as well as a new sequencing-by-synthesis platform (to reduce sequencing costs), sequencing 4,000,000 cells in total.

We divide these profiles across 48 different biological contexts (six cell lines and eight signaling pathways) to explore both conserved and cell type-specific responses to each signaling regulator. We introduce an improved computational framework (Mixscape2) to address cellular variation in perturbation efficiency that is inherent to Perturb-seq experiments, alongside optimized statistical methods to learn differentially expressed gene lists and broader signaling programs. Finally, we demonstrate how our data-driven inference of molecular signatures can be used to precisely infer changes in signaling pathway activation for in-vivo samples, including for immune, metabolic, and intestinal disorders. Our work enhances our understanding of signaling regulators and their targets, and lays a computational framework towards the systematic construction of an ‘atlas’ of perturbation signatures.

Expanding Capabilities in Single Cell Sequencing

Thursday, November 2 | 3:00-3:30 PM | Theater 1

Charlie Roco, PhD
CTO and Cofounder
Parse Biosciences

Single cell experiments are becoming increasingly larger as researchers push the limits on the number of cells and samples profiled in any given experiment. Conventional single cell approaches struggle to keep pace as the path to scalability usually requires an investment in newer hardware or a sacrifice in data quality. The Parse Biosciences combinatorial barcoding platform — Evercode – overcomes these limitations by focusing on chemistry rather than dedicated hardware, providing unprecedented scale and high-quality results. Attend this CoLab to learn more about Evercode, Parse’s entire single cell portfolio, and how the platform compares to other leading single cell technologies.

Poster Presentations

When: November 2, 3:00-5:00 PM
Where: PB3496
Presenter: Efi Papalexi, Parse Biosciences

In this poster, we report on the extension of our highly flexible and scalable combinatorial barcoding technology to allow researchers to profile up to 1 million of T cells in a single experiment and investigate their functional responses during infection, cancer, autoimmunity, or therapeutic interventions.

When: November 4, 2:15-4:15 PM
Where: PB3309
Presenter: Carina Emery, Miltenyi Biotech

In this poster, we present a novel, scalable method for the gentle, rapid isolation of liver cells ideal for scRNA-seq applications. This method holds great promise for furthering our understanding liver diseases, drug discovery, metabolism, and biodistribution.

Single Cell-ebration at ASHG

Join the single cell community as we smash the limits of fun with our 2nd annual Single Cell-ebration.

Spend the evening in Havana enjoying Cuban food, drinks, and live entertainment. Experience rum tastings, cigar rollers, and many more surprises.

We can’t wait to cell-ebrate with you!

When: November 2, 9:00 PM – Midnight
What: Food, entertainment, and open bar 🍹
Where: Cuba Libre, 801 9th St NW, Washington DC (Google Maps)

Visit us at booth #1322

Stop by to chat with our staff about the Evercode technology and pick up some of the coolest swag at the conference! 💜

Booth hours:

  • Thursday, November 2: 9:30 AM–5:00 PM
  • Friday, November 3: 10:00 AM–5:00 PM
  • Saturday, November 4: 10:00 AM–4:30 PM
Schedule a Meeting